TABLE 1.
CXC and CC chemokines in CSF during bacterial meningitis and their demonstrated capacities to exert chemotaxis
| Chemokine | CSFa | Chemotaxisb
|
Reference(s) | |
|---|---|---|---|---|
| In vivo | In vitro | |||
| CXCL1 (GRO-α) | + | + | 71, 103 | |
| CXCL5 (ENA-78) | + | 103 | ||
| CXCL8 (IL-8) | + | +/− | + | 7, 13, 23, 40-42, 50, 52, 67, 71, 72, 86, 103 |
| CCL2 (MCP-1) | + | + | + | 7, 71, 72 |
| CCL3 (MIP-1α) | + | + | 26, 42, 71 | |
| CCL4 (MIP-1β) | + | 71 | ||
| CCL5 (RANTES) | − | + | 7, 71 | |
a
Presence (+) or absence (−) of CXC and CC chemokines in CSF from patients with bacterial meningitis.
b
Demonstrated capacity to exert chemotactic activity in vivo and in vitro.