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C. burnetii and granulomas in tissues. Wild-type and CD28−/− mice were infected i.p. with 5 × 105 C. burnetii organisms and killed at day 7. (A) Bacteria were revealed by immunostaining of the spleen and the liver. (B) Granulomas were revealed by histochemical analysis of the spleen and the liver. Representative micrographs are shown.
