MyD88 deficiency does not cause increased arthritis or carditis in B. burgdorferi-infected mice. MyD88−/− and MyD88+/+ mice were infected with B. burgdorferi as described in Materials and Methods and were sacrificed 2 weeks after infection. Representative HE-stained sections of joints (A to D) and heart (E and F) of both wild-type (A, B, and E) and MyD88−/− (knockout) (C, D, and F) mice are shown. B and D are the magnified pictures of the boxed areas of A and B, respectively. The insets are the magnified views of the areas in the boxes.