FIG. 4.

MyD88 deficiency alters B. burgdorferi-induced proinflammatory cytokine expression patterns. MyD88^−/− (knockout [KO]) and MyD88^+/+ (wild-type [WT]) mice were injected with B. burgdorferi (Bb) or sham as described in Materials and Methods and sacrificed 2 weeks after infection. Total RNA was extracted from the muscle (A), kidney (B), and joint (cartilage) (C), and expression of IFN-γ, IL-10, TNF-α, IL-12p40, IL-12p35, and GM-CSF was examined by real-time RT-PCR. P values at the top of individual graphs are comparisons between infected wild-type and knockout mice. The scales on the y axis are different for each individual graph. ICAM-1, intercellular adhesion molecule 1.