FIG. 5.

MyD88 deficiency alters B. burgdorferi-induced proinflammatory chemokine expression patterns. MyD88^−/− (knockout [KO]) and MyD88^+/+ (wild-type [WT]) mice were injected with B. burgdorferi (Bb) or sham as described in Materials and Methods and sacrificed 3 weeks after infection. Total RNA was extracted from the muscle (A), kidney (B), and joint (cartilage) (C), and expression of CXCL-1, CXCL-2, MIP-1α, MIP-1β, MCP-1, and RANTES was examined by real-time RT-PCR. P values at the top of individual graphs represent comparisons between infected wild-type and knockout mice. The scales on the y axis are different for each individual graph.