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TABLE 1.

Challenge survival following intradermal immunizationa

Treatment group No. of survivors/total no. of mice challenged with strain:
K96243 NCTC 4845 576
DC + CpG in culture 9/10 7/10 7/10
DC + CpG adjuvant 7/10 6/10 6/10
Control ODN 3/8 2/8 3/8
DC only 2/10 1/10 2/10
Naïve 0/8 0/8 0/8
a

Immunization was performed with DCs pulsed with heat-killed B. pseudomallei K96243, with or without CpG ODN treatment. Challenge was performed with approximately 104 CFU strain K96243, NCTC 4845, or 576 by the intraperitoneal route and survival at day 42 was recorded.