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Diminished BLC secretion in NIK−/− cells. BMDM were stimulated for 24 h (LPS, 0.04 ng/ml; MDP, 20 μg/ml) and the production of cytokine and chemokine were determined by specific ELISA. Data are presented as means ± standard deviations of triplicate wells. *, P < 0.05, and **, P < 0.01, for cytokine concentrations from knockout mice compared with data from wild-type mice. Results are representative of three independent experiments.
