FIG. 4.

Mice lacking nNOS exhibit decreased gastrointestinal transit and increased susceptibility to Giardia infection. (A) Adult mice deficient for nNOS (nNOS^−/−) and their wild-type littermate controls (WT) were tested for gastrointestinal motility using a carmine dye test meal. Values are means ± SEM for at least three animals. *, P < 0.05 (t test), relative to the results for wild-type mice. (B) Mice were infected orally with 10⁷ trophozoites of G. lamblia GS/M, and trophozoite numbers in the small intestine were determined at the indicated times after infection. Values are means ± SEM for three to four animals. *, P < 0.05, relative to the counts on day 4.