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Intact females: effects of estrous stage on basal nociception on the 50°C hotplate test in sham-GDX females (D, diestrus-1; P, proestrus; E, estrus). Each bar is the mean + 1 SEM of seven to ten rats. *Significantly different from sham-D, P ≤ 0.05, Student–Newman–Keuls.
