Skip to main content
. Author manuscript; available in PMC: 2006 Mar 29.
Published in final edited form as: Pain. 2003 Jun;103(3):285–302. doi: 10.1016/s0304-3959(02)00457-8

Table 2.

Treatment groups

Group Surgery Steroid hormone capsules Steroid hormone injection (4-day cycle) Treatment abbreviation
Males
1 Sham-orchidectomy Blank Vehicle Sham
2 Orchidectomy Blank Vehicle GDX + 0
3 Orchidectomy Ta Vehicle GDX + T
4 Orchidectomy E2 Vehicle GDX + E2
5 Orchidectomy DHT Vehicle GDX + DHT
6 Orchidectomy E2 + DHT Vehicle GDX + E2/DHT
Intact femalesb
7 Sham-ovariectomy Blank Vehicle Sham-diestrus-1 (D)
8 Sham-ovariectomy Blank Vehicle Sham-proestrus (P)
9 Sham-ovariectomy Blank Vehicle Sham-estrus (E)
GDX females
10 Ovariectomy Blank Vehicle GDX + 0
11 Ovariectomy E2c Vehicle GDX + E2
12 Ovariectomy E2c P4 GDX + E2/P4
13 Ovariectomy Blank P4 GDX + P4
14 Ovariectomy T Vehicle GDX + T
a

In GDX males, two doses of T were tested: ‘low’, one 2-mm capsule/100 g body weight; ‘high’, one 10-mm capsule/100 g body weight.

b

No sham females were tested during diestrus-2 because, in terms of gonadal steroid levels, reproductive behavior and reproductive physiology, there are few differences between diestrus-1 and -2 (Freeman, 1988).

c

In GDX females, two doses of E2 were tested: ‘low’, one 1-mm capsule/rat; ‘high’, one 5-mm capsule/rat.