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. Author manuscript; available in PMC: 2006 Mar 29.

Published in final edited form as: Pain. 2003 Jun;103(3):285–302. doi: 10.1016/s0304-3959(02)00457-8

Table 3.

ED₅₀ values (mean ± 1 SEM) for morphine antinociception on the 50°C hotplate^a

Males			Females
Treatment group	ED₅₀	N	Treatment group	ED₅₀	N
			Sham-D	5.65 ± 0.60	9
			Sham-P	6.82 ± 1.26	7
Sham	5.61 ± 0.88^,^*	8	Sham-E	10.46 ± 0.93^,^**	10
GDX + 0	9.49 ± 0.93	11	GDX + 0	6.43 ± 1.05	11
GDX + T (low)	5.30 ± 0.64^*	8	GDX + E2 (low)	15.61 ± 1.26^*	11
GDX + T (high)	5.34 ± 0.90^*	8	GDX + E2 (high)	10.07 ± 1.35	9
GDX + E2	10.35 ± 1.43	11	GDX + E2 (low)/P4	13.10 ± 1.05^*	8
GDX + DHT	10.91 ± 1.93	7	GDX + E2 (high)/P4	11.60 ± 1.00^*	10
GDX + E2/DHT	6.80 ± 0.89	10	GDX + P4	6.31 ± 1.18	11
			GDX + T	14.03 ± 1.81^*	10

^a

For treatment group abbreviations see Table 2.

^*

Significantly different from GDX + 0 rats of the same sex, P ≤ 0.05, Dunnett's.

^**

Significantly different from sham-E females, P ≤ 0.05, t-test

^***

Significantly different from sham-D and sham-P female rats, P ≤ 0.05, Student–Newman–Keuls.