Figure 3.

A comparison of the mean steady state ECM accumulation with supplemented growth factor effects. Steady state values of growth factor-influenced accumulation are calculated from the means of the probability functions, ${\overline{P}}_{\infty }(ECM)$, applied to equations (24) and (25) and shown for each constituent in equation (26). ECM growth and density rates were incorporated from representative published cartilage engineering experiments (Table 1): A) Freed et al.²⁹; B) Vunjak-Novakovic et al.³⁰; C) Wilson et al.⁹; and D) Vunjak-Novakovic et al.³¹. For each ECM constituent, mean accumulation values are determined at distinct relative growth factor levels within the Stochastic Treated Model, ρ_GAG = ρ_collagen = 0.3, 0.5, 0.8, 1.0, and 2.0. Accumulation at ρ₀ = 0 represents the mean steady state level from the Deterministic Control Model.