Table 1.
Representative ECM synthesis parameters previously derived from a cartilage tissue engineering model applied to published experimental data.9 Growth (α) and decay (β) rates are further extracted in this work from the Deterministic Control Model. Note: PGA = polyglycolic acid scaffold; BAC = bovine articular cartilage;τECM = matrix molecule characteristic time constants; dw = dry weight; ww = wet weight.
| Growth (α), Decay (β) Rates | ||||||||
|---|---|---|---|---|---|---|---|---|
| Scaffold | Cell type | Ref | GAGss | τGAG | Collagenss | τcollagen | αGAG βGAG | αcollagen βcollagen |
| PGA | BAC | 29 | 6.8%
ww |
31.3
days |
3.7%
ww |
15.9
days |
3.256 x 10−2
6.139 x 10−4 |
6.672 x 10−2
3.837 x 10−3 |
| PGA | BAC | 30 | 11.7%
dw |
18.6
days |
50.4%
dw |
131.5
days |
5.441 x 10−2
3.662 x 10−4 |
7.607 x 10−3
2.937 x 10−6 |
| PGA | BAC | 9 | 6.1%
dw |
187.0
days |
6.5%
dw |
18.9
days |
5.474 x 10−3
1.264 x 10−4 |
5.400 x 10−2
1.108 x 10−3 |
| PGA | BAC | 31 | 1.6%
ww |
22.2
days |
2.4%
ww |
16.7
days |
5.900 x 10−2
1.400 x 10−2 |
6.800 x 10−2
8.363 x 10−3 |