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. 2006 Mar 31;2(3):e30. doi: 10.1371/journal.pcbi.0020030

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© 2006 Guantes and Poyatos.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Only the 1:1 (red) and 1:2 (blue) stable resonance regions are shown. ω₀ is the limit cycle frequency (the undriven system is in the oscillatory regime at Δ = 11 for Design I and Δ = 22 for Design II, respectively), and ω denotes the signal frequency. The (scaled) signal amplitude δ_RS affects the repressor degradation (see Supporting Information). Positive values (top panels) increase degradation and decrease the value of Δ while negative values (bottom panels) decrease degradation and increase the value of Δ. Solid lines: critical values of signal amplitude for effectively driving the system towards the rest state.