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. 2006 Mar 29;34(6):1721–1734. doi: 10.1093/nar/gkl063

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© The Author 2006. Published by Oxford University Press. All rights reserved

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Biosynthesis of the MTM analogs SDK and SK. (A) The oxygenase MtmOIV and ketoreductase MtmW catalyze the conversion of premithramycin B to mithramycin (MTM). Inactivation of MtmW prevents synthesis of MTM and results in accumulation of the intermediate product DK, which is then converted into SK and SDK. Regions of relevant MTM-DNA interaction are indicated. (B) Side chain rearrangements leading to formation of SK and SDK from the MtmOIV product DK.