Figure 5. Localization of hepatic leukocyte accumulation. (A) (Periportal region) Allopurinol and N-acetylcysteine significantly decreased leukocyte accumulation after shock/resuscitation (S/R). This accumulation peaked at 6 hours but was still significantly decreased at 24 hours in the allopurinol and N-acetylcysteine groups. The WEB 2170 group also showed a peak neutrophil accumulation at 6 hours, but the number of leukocytes was not significantly decreased compared with the S/R alone group at either 6 or 24 hours. (B) (Midzone) Leukocyte accumulation peaked at 6 hours but was not significantly reduced with allopurinol, N-acetylcysteine, or WEB 2170 treatment at either 6 or 24 hours. (C) (Pericentral region) Pericentral leukocyte accumulation was significantly decreased by allopurinol, N-acetylcysteine, and WEB 2170 treatment at both 6 and 24 hours compared with the S/R alone group. *P < .05 versus S/R alone; **P < .001 versus S/R alone.