Figure 8. Loss of hepatocyte viability. (A) The mild degree of injury in the periportal region was not significantly affected by treatment, compared with the shock/resuscitation (S/R) alone group. (B) Similar to the periportal region, the midzone also did not show significant reduction in the mild degree of injury with treatment. (C) Although the pericentral region was most injured by S/R, these parameters did not reflect significant protection by treatment with allopurinol, N-acetylcysteine, or WEB 2170. **P < .05 versus S/R alone.