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Growth retardation of AQP2-total-KO mice. A 10-day-old wild-type mouse (A) and a AQP2-total-KO mouse (B) from the same litter. The AQP2-total-KO mouse grew markedly less. (C) The growth of AQP2-total-KO and wild-type mice over time. All AQP2-total-KO mice died before day 13, whereas all controls survived.
