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. 2006 Apr 3;116(4):984–995. doi: 10.1172/JCI25790

Figure 10. Lower levels of GSH in the lungs and MEFs of Nrf2-deficient mice.

Figure 10

(A) Constitutive expression of GCLC in lungs and MEFs of Nrf2+/+ and Nrf2–/– mice. (B) GSH levels in the lungs of mice of both genotypes 24 hours after LPS instillation (10 μg per mouse). Data are mean α SEM from 3 independent experiments and are expressed as percentage increases relative to vehicle-treated Nrf2+/+ group. (C) Ratio of GSH to GSSG measured 24 hours after LPS instillation in the lung of Nrf2+/+ and Nrf2–/– mice. Data are mean α SEM from 3 independent experiments. (D) GSH levels in Nrf2+/+ and Nrf2–/– MEFs at 1 hour after LPS (0.5 μg/ml) or TNF-α (10 ng/ml) stimulus. Data are presented as mean α SEM; n = 4. *Differs from vehicle control of the same genotype. †Differs from wild-type treatmt group. P < 0.05.