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. 2006 Apr 3;116(4):984–995. doi: 10.1172/JCI25790

Figure 7. Lack of Nrf2 augments NF-κB activation in macrophages.

Figure 7

(A) Nuclear extracts of Nrf2+/+ and Nrf2–/– peritoneal macrophages were assayed for NF-κB DNA-binding by EMSA 20 minutes after LPS treatment (1 ng/ml). (B) Densitometric analysis of NF-κB DNA-binding relative to wild-type vehicle control. Values are mean α SEM; n = 3. (C) TNF-α levels in the culture media from Nrf2+/+and Nrf2–/–peritoneal macrophages after 0.5 hours, 1 hours, and 3 hours of LPS treatment (1 ng/ml). *Differs from vehicle control of the same genotype. †Differs from wild-type treatment grou P < 0.05.