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Chk2 and 14-3-3 cooperate to neutralize MDMX inhibition of p53. (A) HCT116-Chk2−/− cells were transfected with p53-responsive BP100-luc reporter to detect endogenous p53 transcriptional activity. The effects of wild-type MDMX, 14-3-3 and Chk2 coexpression on p53 activity were detected by luciferase assay and normalized to CMV-lacZ transfection efficiency control. (B) A control experiment identical to (A), except that the MDMX 367A mutant was used.
