Figure 4. Intraperitoneal glucose tolerance test (IPGTT). Mice were randomized to three different groups (basal, 30 minutes, and 60 minutes) and fasted overnight. The following day the basal group mice were anesthetized and had blood drawn from the retroorbital sinus. The 30- and 60-minute mice received an intraperitoneal injection of glucose at 1.2 mg/g body weight and at the appropriate time after glucose injection were anesthetized and underwent blood draw. (A) Glucose levels for IPGTT. αP < .05, WT versus Sur1 KO at basal and 60 minutes, βP < .05, SSTR5 versus Sur/SSTR5 KO at 30 and 60 minutes, ρP < .05, Sur/SSTR5 KO versus Sur1 KO at basal and 60 minutes, *P < .05, SSTR5 KO versus Sur1 KO at basal and 60 minutes, #P < .05, WT versus Sur/SSTR5 KO at 30 and 60 minutes. (B) Insulin levels for IPGTT. αP < .05, WT versus Sur/SSTR5 KO at basal and 30 minutes, βP < .05, WT versus Sur1 KO at 30 minutes, *P < .05, Sur/SSTR5 KO versus SSTR5 KO at basal.