Figure 4. Leakage of fluorescein isothiocyanate conjugated to bovine serum albumin (FITC-BSA) from the intestinal villus microcirculation in control animals and ischemia–reperfusion (I/R) animals subjected to normothermic and hypothermic conditions. Control animals (•-•); normothermic I/R animals (○-○); hypothermic I/R animals (□-□); rewarmed hypothermic I/R animals (▵-▵). *P < .05, **P < .01 versus control (Mann-Whitney test). No comparisons were performed after 105 minutes in the normothermic group because only two animals survived beyond this point. Data are means ± standard error of the mean. The body temperature profile of rewarmed hypothermic animals is indicated. Data presented are for the reperfusion phase.