Figure 1. Effect of calcineurin inhibitors on anti-CD154 mAb therapy in the C57BL/6 into BALB/c cardiac transplant model. The concomitant use of cyclosporine or tacrolimus abrogated the effect of single-dose anti-CD154 mAb on cardiac allograft survival (P = .017 and P = .003, respectively, vs. sMR1 alone).