Figure 2. Dose-dependence of the NAADP-induced Ca²⁺ release in rat liver microsomes.

Microsomes were actively loaded with Ca²⁺ in the presence of 1 mM ATP and were assayed for Ca²⁺ release using different concentrations of NAADP in the range 0.01–10 μM. Results are means±S.E.M. for five independent experiments.