Figure 2. Resting [Ca²⁺] of EBV-immortalized lymphoblastoid cells from control individuals and individuals bearing different RyR1 mutations.

Average resting myoplasmic [Ca²⁺] of cells from controls and individuals bearing the indicated RyR1 mutations. Values are means±S.E.M. (n=43–98). Data were determined in fura-2-loaded lymphoblastoid cells (1×10⁶ cells/ml) in nominally Ca²⁺-free Krebs–Ringer solution supplemented with 0.5 mM EGTA. [Ca²⁺]_i was measured using the fluorescent Ca²⁺ indicator fura 2. *, P<0.04. homo, homozygous; hetero, heterozygous; WT, wild-type.