Table 2. Number of lymphoblastoid cells carrying RyR1 substitutions, responding to different concentrations of caffeine and 4-cmc.
The number of cells analysed was in the range 15–302.
| (a) | |||||
|---|---|---|---|---|---|
| Responding cells (% of total) | |||||
| [Caffeine] (mM)… | 0.5 | 2.5 | 5 | 10 | 20 |
| Control | 21.6 | 21.3 | 25 | 29.2 | 22.9 |
| R999H heterozygous | 18.1 | 21.7 | 25 | 14.3 | 17 |
| P3527S homozygous | 11.6 | 14.9 | 10.6 | 10 | 17.6 |
| P3527S heterozygous | 20.1 | 33 | 22.4 | 20 | 18.4 |
| V4849I homozygous | 26.3 | 43.8 | 40 | 18.3 | 17.8 |
| V4849I heterozygous | 20.2 | 35.6 | 14.6 | 18.9 | 19.2 |
| (b) | |||||
| Responding cells (% of total) | |||||
| [4-cmc] (μM)… | 75 | 150 | 300 | 600 | 1000 |
| Control | 31.6 | 40 | 39.3 | 61.3 | 29.7 |
| R999H heterozygous | 20.7 | 26.7 | 47.4 | 30.3 | 32 |
| P3527S homozygous | 41.7 | 42.9 | 38.5 | 50 | 39.3 |
| P3527S heterozygous | 29.4 | 29.1 | 53.8 | 50 | 22.5 |
| V4849I homozygous | 35.7 | 40 | 35 | 26.1 | 34.8 |
| V4849I heterozygous | 38.9 | 47.6 | 60 | 57.9 | 60 |