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. 1974 Jan;26(1):175–186.

The cellular origin of the lymphocyte trap

P Frost, E M Lance
PMCID: PMC1423101  PMID: 4546490

Abstract

We investigated the cellular requirements for lymphocyte trapping. Depletion of lymphocyte populations selectively or indiscriminately did not affect the ability of animals to trap. The variety of materials which initiate trapping was also studied and this information, coupled with the resistance of `trapping' to severe lymphocyte depletion, is consistent with the hypothesis that the macrophage may be the central cell in initiating the trapping of lymphocytes after antigen stimulation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C., Harington J. S., Birbeck M. An examination of the cytotoxic effects of silica on macrophages. J Exp Med. 1966 Aug 1;124(2):141–154. doi: 10.1084/jem.124.2.141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Argyris B. F., Plotkin D. H. Effects of antimacrophage, antithymocyte, antilymphocyte and antispleen serum on the immune response in mice. Clin Exp Immunol. 1970 Oct;7(4):551–564. [PMC free article] [PubMed] [Google Scholar]
  3. BENACERRAF B., KIVY-ROSENBERG E., SEBESTYEN M. M., ZWEIFACH B. W. The effect of high doses of x-irradiation on the phagocytic, proliferative, and metabolic properties of the reticulo-endothelial system. J Exp Med. 1959 Jul 1;110(1):49–64. doi: 10.1084/jem.110.1.49. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cohen J. J., Claman H. N. Thymus-marrow immunocompetence. V. Hydrocortisone-resistant cells and processes in the hemolytic antibody response of mice. J Exp Med. 1971 May 1;133(5):1026–1034. doi: 10.1084/jem.133.5.1026. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Davies A. J., Leuchars E., Wallis V., Koller P. C. The mitotic response of thymus-derived cells to antigenic stimulus. Transplantation. 1966 Jul;4(4):438–451. doi: 10.1097/00007890-196607000-00008. [DOI] [PubMed] [Google Scholar]
  6. Dresser D. W., Taub R. N., Krantz A. R. The effect of localized injection of adjuvant material on the draining lymph node. II. Circulating lymphocytes. Immunology. 1970 May;18(5):663–670. [PMC free article] [PubMed] [Google Scholar]
  7. Flemming K., Flemming C., Nothdurft W. The phagocytic activity of the reticuloendothelial system of mice following whole-body x-irradiation. J Reticuloendothel Soc. 1970 Jan;7(1):1–14. [PubMed] [Google Scholar]
  8. Ford W. L. Duration of the inductive effect of sheep erythrocytes on the recruitment of lymphocytes in the rat. Immunology. 1968 Oct;15(4):609–617. [PMC free article] [PubMed] [Google Scholar]
  9. Grogan J. B. Reticuloendothelial system function after single and multiple injections of antilymphocyte serum. J Reticuloendothel Soc. 1970 Dec;8(6):561–570. [PubMed] [Google Scholar]
  10. Hall J. G., Morris B. The immediate effect of antigens on the cell output of a lymph node. Br J Exp Pathol. 1965 Aug;46(4):450–454. [PMC free article] [PubMed] [Google Scholar]
  11. Haugen J., Bassoe H. H., Flood P. R. Phagocytosis in rabbits treated with oxyphenbutazone and cortisone, studied by gold clearance test and electron microscopy. J Reticuloendothel Soc. 1969 Apr;6(2):184–193. [PubMed] [Google Scholar]
  12. Herman P. G., Yamamoto I., Mellins H. Z. Blood microcirculation in the lymph node during the primary immune response. J Exp Med. 1972 Oct 1;136(4):697–714. doi: 10.1084/jem.136.4.697. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Jooste S. V., Lance E. M., Levey R. H., Medawar P. B., Ruszkiewicz M., Sharman R., Taub R. N. Notes on the preparation and assay of anti-lymphocytic serum for use in mice. Immunology. 1968 Nov;15(5):697–705. [PMC free article] [PubMed] [Google Scholar]
  14. Kinnaert P., Mahieu A., Penneman R. Effect of different types of antilymphocytic serum on phagocytosis in rats. J Reticuloendothel Soc. 1972 Nov;12(5):525–536. [PubMed] [Google Scholar]
  15. Lake W. W., Bice D., Schwartz H. J., Salvaggio J. Suppression of in vitro antigen-induced lymphocyte transformation by carrageenan, a macrophage-toxic agent. J Immunol. 1971 Dec;107(6):1745–1751. [PubMed] [Google Scholar]
  16. Lance E. M., Cooper S. Effects of cortisol and antilymphocyte serum on lymphoid populations. Ciba Found Study Group. 1970;36:73–99. [PubMed] [Google Scholar]
  17. Lance E. M. The selective action of antilymphocyte serum on recirculating lymphocytes: a review of the evidence and alternatives. Clin Exp Immunol. 1970 Jun;6(6):789–802. [PMC free article] [PubMed] [Google Scholar]
  18. Levey R. H., Medawar P. B. Nature and mode of action of antilymphocytic antiserum. Proc Natl Acad Sci U S A. 1966 Oct;56(4):1130–1137. doi: 10.1073/pnas.56.4.1130. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Perkins E. H., Nettesheim P., Morita T. Radioresistance of the engulfing and degradative capacities of peritoneal phagocytes to kiloroentgen x-ray doses. J Reticuloendothel Soc. 1966 May;3(1):71–82. [PubMed] [Google Scholar]
  20. Sharbaugh R. J., Grogan J. B. Suppression of reticuloendothelial function in the rat with cyclophosphamide. J Bacteriol. 1969 Oct;100(1):117–122. doi: 10.1128/jb.100.1.117-122.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Taub R. N. Effects of heterologous antilymphocyte serum on lymphoid cells labeled with 5-iodo-2-deoxyuridine-125-I. Fed Proc. 1970 Jan-Feb;29(1):142–144. [PubMed] [Google Scholar]
  22. Taub R. N., Gershon R. K. The effect of localized injection of adjuvant material on the draining lymph node. 3. Thymus dependence. J Immunol. 1972 Feb;108(2):377–386. [PubMed] [Google Scholar]
  23. Taub R. N., Lance E. M. Effects of heterologous anti-lymphocyte serum on the distribution of 51-Cr-labelled lymph node cells in mice. Immunology. 1968 Nov;15(5):633–642. [PMC free article] [PubMed] [Google Scholar]
  24. Turk J. L., Poulter L. W. Selective depletion of lymphoid tissue by cyclophosphamide. Clin Exp Immunol. 1972 Feb;10(2):285–296. [PMC free article] [PubMed] [Google Scholar]
  25. Zatz M. M., Lance E. M. Lymphocyte trapping in tolerant mice. Nat New Biol. 1971 Dec 22;234(51):253–254. doi: 10.1038/newbio234253a0. [DOI] [PubMed] [Google Scholar]
  26. Zatz M. M., Lance E. M. The distribution of 51Cr-labeled lymphocytes into antigen-stimulated mice. Lymphocyte trapping. J Exp Med. 1971 Jul 1;134(1):224–241. doi: 10.1084/jem.134.1.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. van Furth R., Cohn Z. A., Hirsch J. G., Humphrey J. H., Spector W. G., Langevoort H. L. The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells. Bull World Health Organ. 1972;46(6):845–852. [PMC free article] [PubMed] [Google Scholar]

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