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. 1963 Jul;6(4):331–344.

Immunological Relation of Basement Membrane and a Serum Beta Globulin in the Mouse

Demonstration of Renal Basement Membrane Alteration in Mice Injected with Streptolysin S

E M Tan, M H Kaplan
PMCID: PMC1423333  PMID: 14042900

Abstract

Antiserum to a fraction of mouse β globulin isolated by electrophoresis and column chromatography was found reactive by immunofluorescence with renal basement membrane of glomeruli and tubules, and with basement membrane and connective tissue in other organs. This method for staining renal basement membrane was applied to the study of renal lesions produced in mice by streptolysin S. In lesions characterized by early changes of acute tubular necrosis a marked decrease in ability to stain tubular basement membrane was observed. Reappearance of staining property in basement membrane was linked to re-regeneration of diseased tubules. Repeated injections of streptolysin S produced alterations in staining also of glomerular basement membrane

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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