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. 1964 Nov;7(6):639–656.

Characterization of human antibodies to Salmonella typhi by gel-filtration and antigenic analysis

M W Turner, D S Rowe
PMCID: PMC1423404  PMID: 14239839

Abstract

A normal adult human male was immunized with a heat-killed typhoid vaccine. The appearance of antibodies to `H' and `O' antigens was subsequently studied. Antibodies were identified as belonging to specific immunoglobulin classes by gel-filtration on G-200 `Sephadex', followed by specific immunochemical identification using a two-stage agglutination test. Serum antibodies to `H' antigen were initially of γ1M class; later the 7S γ class became predominant. γ1A antibodies were transient in appearance. Serum antibodies to `O' antigen were of γ1M and γ1A classes. Urinary antibodies to `H' antigen were of γ1A and 7S γ classes. No antibody activity could be detected in the low molecular weight γ-globulins of urine.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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