Abstract
Guinea-pigs injected with antigen in Freund's complete adjuvant develop delayed hypersensitivity to the antigen. This is reduced by the prior injection of the same antigen precipitated with alum. This may be termed immune deviation and has been shown to differ from immune tolerance. Four possible mechanisms for this phenomenon were considered: (a) that there was a specific defect in the cell population responsible for the passive transfer of delayed hypersensitivity; (b) that there was an antibody blocking the detection of delayed hypersensitivity; (c) that there was an antibody blocking the induction of delayed hypersensitivity; and (d) that the cells responsible for delayed hypersensitivity were desensitized in vivo. Experiments on the passive transfer of delayed hypersensitivity from deviated and control guinea-pigs showed that there was a defect in the cell population involved in the passive transfer of delayed hypersensitivity. Serum transfer failed to reveal evidence of antibody blocking the induction or detection of delayed hypersensitivity. Transfer of cells into recipients which had been pretreated with alum-precipitated antigen gave no evidence of desensitization in the PPD system. The findings with bovine γ-globulin were equivocal. It was concluded that there was a defect in the cell population involved in the passive transfer of delayed hypersensitivity and, in the absence of evidence for other mechanisms, this was attributed to a direct effect of the first injection of antigen on the cells responsible for the state of delayed hypersensitivity after the injection of the same antigen in Freund's complete adjuvant.
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Selected References
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- Asherson G. L., Stone S. H. Selective and specific inhibition of 24 hour skin reactions in the guinea-pig. I. Immune deviation: description of the phenomenon and the effect of splenectomy. Immunology. 1965 Sep;9(3):205–217. [PMC free article] [PubMed] [Google Scholar]
- KALISS N. Immunological enhancement of tumor homografts in mice: a review. Cancer Res. 1958 Oct;18(9):992–1003. [PubMed] [Google Scholar]
- Loewi G., Holborow E. J., Temple A. Inhibition of delayed hypersensitivity by pre-immunization without complete adjuvant. Immunology. 1966 Apr;10(4):339–347. [PMC free article] [PubMed] [Google Scholar]
- UHR J. W., BAUMANN J. B. Antibody formation. I. The suppression of antibody formation by passively administered antibody. J Exp Med. 1961 May 1;113:935–957. doi: 10.1084/jem.113.5.935. [DOI] [PMC free article] [PubMed] [Google Scholar]