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. Author manuscript; available in PMC: 2006 Apr 4.

Published in final edited form as: J Am Chem Soc. 2003 Dec 3;125(48):14702–14703. doi: 10.1021/ja0384734

Scheme 5a — (a)3, Et₂Zn, PhMe, Δ, then (R)-BINOL, Ti(OⁱPr)₄, THF, 4,0 °C, 81%; (b) TIPSOTf, pyridine, DMAP, THF, 0 °C, 96%; (c) (NH₄)₂Ce(NO₃)₆, MeCN/H₂O, -10 °C, 91%; (d) 2, ⁱPr₂SiCl₂ (xs), CH₂Cl₂, imidazole, 0 °C to room temperature, then 14, imidazole, 0 °C to room temperature, 74%; (e) Grubbs' catalyst (1.8 equiv), 1,2-DCE, Δ, 83%; (f) HF/MeCN, CH₂Cl₂, room temperature, 91%; (g) TsNHNH₂, NaOAc, 1,2-DME/H₂O, Δ, 95%.