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. 2006 Jan 31;78(4):575–587. doi: 10.1086/501372

Figure 4.

Figure 4

Activities of TH, TPH, and PAH. To determine the TH enzyme activity, dopamine (A), DOPAC (B), and norepinephrine (C) levels were measured in the caudate putamen (CPu), cortex (CTX), and cerebellum (CBL). For TPH activity, serotonin (D) and 5-HIAA (E) levels were measured in the CTX and CBL. Three Spr+/+, five Spr+/−, and three Spr−/− mice were analyzed. Values are means (and SE is indicated above each bar). *P<.01 and **P<.05, compared with Spr+/+ mice, as determined by Student’s t test. F, Phenylalanine levels of 28–44-d-old mice were measured to determine the functional PAH enzyme activity. Pahenu2 mice harbor a mutation in the Pah gene that is generated by N-ethyl-N-nitrosourea (ENU) mutagenesis. Five Spr+/+ or Spr+/− mice (controls), 5 Spr−/− mice, and 10 Pahenu2 mice were used. Values are means (and SE is indicated above each bar). *P<.001, compared with Spr+/+ mice, as determined by Student’s t test.