Figure 5.

Expression of TH in the brain. Brain sections from Spr^+/+ (A, C, E, and G) and Spr^−/− (B, D, F, and H) mice were immunostained with anti-TH antibody (A, B, C, D, E, and F) or anti-AADC antibody (G and H). A few unusual TH-immunopositive cells (red arrowheads) and weakly positive fibers (black arrowheads) are indicated in the caudate putamen (CPu) of the Spr^−/− brain (F). Images E and F are magnified (×400) views of the CPu regions in images C and D (original magnification ×5), respectively. All mice were 4 wk old. SN = substantia nigra; VTA = ventral tegmental area.