Figure 6.

Behavioral defects in Spr^−/− mice. A, Four-limb akinesia test. The mice were picked up by the tail and slowly placed on a surface. The time that it took for the mice to move all four limbs was recorded. B, Turning test. The mice were placed head-down on a screen positioned at the edge of a countertop and tilted 60° from the surface. The time required for the mice to reorient themselves in the opposite direction was recorded. The maximum time for each set of these tests was 2 min. Four mice of each genotype were used. Values are means (and SE is indicated above each bar). *P⩽.001, compared with the Spr^+/+ mice, as determined by Student’s t test.