Table 1.
Effects of Repeated Oral Administration of BH4 and Neurotransmitters[Note]
|
Level in Brain(pmol/mg of protein) |
Level in Liver(pmol/mg of protein) |
|||||||
|
Treatment and Mice |
Neopterin | Total Biopterin |
BH4 | Sepiapterin | Neopterin | Total Biopterin |
BH4 | Sepiapterin |
| None: | ||||||||
| Spr+/+ | .17 ± .06 | 8.85 ± .58 | 5.97 ± .42 | ND | .21 ± .06 | 43.41 ± 2.49 | 38.57 ± 1.80 | ND |
| Spr+/− | .29 ± .04 | 15.81 ± .94 | 4.67 ± .60 | ND | .35 ± .08 | 39.28 ± 1.87 | 32.36 ± 1.92 | ND |
| Spr−/− | .89 ± .08 | 3.42 ± .40 | 2.42 ± .31 | 4.75 ± .43 | .71 ± .10 | 1.94 ± .44 | .42 ± .32 | 5.47 ± 1.04 |
| Low dose: | ||||||||
| Spr+/+ | .77 | 8.69 | 5.76 | ND | .37 ± .04 | 39.44 ± 5.12 | 34.89 ± 5.74 | ND |
| Spr+/− | .41 | 13.44 | 8.64 | ND | .5 ± .07 | 49.23 ± 1.3 | 45.65 ± 1.19 | ND |
| Spr−/− | .91 ± .16 | 6.30 ± 2.34 | .58 ± .05 | 6.22 ± .88 | .5 | 1.89 | .33 | 9.05 |
| High dose: | ||||||||
| Spr+/+ | .2 ± .03 | 8.99 ± .33 | 7.24 ± .42 | ND | .33 ± .01 | 41.41 ± 2.71 | 36.92 ± 4.16 | ND |
| Spr+/− | .36 ± .22 | 8.58 ± 1.01 | 6.50 ± 2.01 | ND | .31 ± .06 | 48.90 ± 1.62 | 45.64 ± 1.34 | ND |
| Spr−/− | .53 ± .06 | 4.00 ± 1.17 | 1.77 ± .37 | 5.68 ± .58 | .34 ± .03 | 3.82 ± 1.1 | 1.86 ± .60 | 8.72 ± .46 |
Note.— ND = not detectable.