Table 2.
MIC90 of tigecycline and the tetracyclines in vitro∗
| Organism | Tigecycline | Tetracycline | Doxycycline | Minocycline |
| Gram-positive | ||||
| Staphylococcus aureus, methicillin susceptible | 0.12–0.5 | 1 | 0.5 | 0.12 |
| Staphylococcus aureus, methicillin resistant | 0.25–5 | 32 | 2 | 2 |
| Staphylococcus epidermidis, methicillin susceptible | 0.5 | 2 | NA | 0.5 |
| Staphylococcus epidermidis, methicillin resistant | 0.5 | >8 | NA | 4 |
| Streptococcus pneumoniae, penicillin sensitive | 0.06–0.125 | 32 | 8 | 8 |
| Streptococcus pneumoniae, penicillin intermediate | 0.06 | 64 | 8 | 16 |
| Streptococcus pneumoniae, penicillin resistant | 0.06–0.125 | 64 | 8 | 16 |
| Streptococcus pyogenes | 0.06 | 4 | 0.5 | 0.25 |
| Enterococcus faecalis | 0.12–0.25 | 128 | 16 | 32 |
| Enterococcus faecium | 0.12–0.25 | 64 | 16 | 16 |
| Gram-negative | ||||
| Acinetobacter spp. | 2 | >32 | NA | 1 |
| Burkholderia cepacia | 32 | 4 | NA | 2 |
| Citrobacter freundii | 0.5–2 | 8 | NA | 8 |
| Enterobacter aerogenes | 1 | 4 | NA | 2 |
| Enterobacter cloacae | 0.5–4 | >8 | NA | >8 |
| Escherichia coli | 0.5 | >8 | NA | 8 |
| Klebsiella pneumoniae | 1–2 | 4 | NA | 4 |
| Moraxella catarrhalis | 0.12 | 0.25 | NA | 0.06 |
| Morganella morganii | 4–8 | 16 | NA | 4 |
| Proteus mirabilis | 8 | 32 | NA | 16 |
| Pseudomonas aeruginosa | 16 | >32 | NA | 32 |
| Stenotrophomonas maltophilia | 2–4 | 32 | NA | 1 |
| Serratia marcescens | 2 | >8 | NA | 8 |
| Haemophilus influenzae | 0.5–1 | 0.5 | NA | 8 |
| Anaerobes | ||||
| Bacteroides fragilis | 2–4 | 32 | 8 | 8 |
| Clostridium difficile | 0.125–0.5 | 0.125 | 0.125 | 0.032 |
| Clostridium perfringens | 0.25–0.5 | 8 | 0.125 | 0.125 |
| Peptostreptococcus spp. | 0.125–0.25 | 16 | 4 | 8 |
| Other | ||||
| Chlamydia pneumoniae | 0.125 | NA | 0.25 | NA |
| Legionella pneumoniae | NA | 1–8 | 4 | 4 |
| Mycoplasma pneumoniae | 0.25 | 1 | 1.6 | 1 |