Table 6.

Selected adverse events with tigecycline therapy^∗

Adverse event	Tigecycline (%, n = 1415)	Comparators (%, n = 1382)
Nausea	29.5	15.8
Vomiting	19.7	10.8
Diarrhea	12.7	10.8
Increased liver enzymes (AST and ALT combined)	9.9	9.1
Localized infusion reactions	9	9.1
Infection	8.3	5.4
Fever	7.1	9.8
Abdominal pain	6.8	5.7
Thrombocythemia	6.1	6.2
Headache	5.9	6.5
Hypertension	4.9	5.6
Dizziness	3.5	2.7
Bilirubinemia	2.3	0.9
Insomnia	2.3	3.3

∗From reference 1. Comparators: vancomycin and aztreonam, imipenem/cilastatin, linezolid.

AST indicates aspartate aminotransferase; ALT, alanine aminotransferase.