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Percentage of the 121 children from 2 to 13 years with a minimum plasma concentration above 0.8 mg/liter as a function of daily dose and frequency of administration. Solid line, administration every 8 h; dotted line, administration every 12 h; vertical line, minimal FDA-recommended doses of 25 mg/kg TID (solid line) and 50 mg/kg BID (dotted line).
