TABLE 2.
Population pharmacokinetic parameters of nelfinavir and metabolite M8 and bootstrap validation
| Parameterb | Final model original data set mean (CV%) | Bootstrapa
|
||
|---|---|---|---|---|
| Mean (CV%) | Median | 2.5th-97.5th percentiles | ||
| Ka (h−1) | 0.48 (32) | 0.46 (28) | 0.45 | 0.26-0.69 |
| V (liters/kg) | 6.86 (28) | 6.98 (31) | 6.76 | 3.58-11.9 |
| CLT (liters/h/kg) | 0.93 (4.6) | 0.92 (4.9) | 0.92 | 0.84-1.00 |
| CLT and V, θAGE | −0.29 (12) | −0.29 (11) | −0.29 | −0.35-−0.23 |
| FMT | 0.025 (15) | 0.025 (27) | 0.024 | 0.009-0.036 |
| KM0 (h−1) | 1.88 (16) | 1.70 (29) | 1.80 | 0.54-2.6 |
| KM0, θINN | 0.91 (25) | 0.98 (29) | 0.92 | 0.55-1.68 |
| Statistical model | ||||
| σNELFI (μg/ml) | 1.65 (8.9) | 1.64 (4.5) | 1.64 | 1.50-1.78 |
| σM8 (μg/ml) | 0.63 (21) | 0.63 (11) | 0.63 | 0.50-0.79 |
| ω(V) (%) | 109 (53) | 112 (19) | 111 | 76-155 |
| ω(CLT) (%) | 39.1 (22) | 38 (9.7) | 38 | 31-46 |
| ω(KM0) (%) | 49.2 (26) | 49 (14) | 49 | 35-62 |
| r(CLT − KM0) | 0.45 (36) | 0.44 (31) | 0.44 | 0.17-0.69 |
a
Statistics from 1,000 bootstrap analyses.
b
CV%, coefficient of variation (standard error of estimate/estimate·100); ω, interindividual variability estimates (CV of intersubject variability, %) and σ residual variability estimates (CV of residual variability, %); r(CLT − KM0), correlation coefficient between ω(CLT) and ω(KM0).