TABLE 2.

Pharmacokinetic model-building summary for L-AmB

Model no.	Modela	Compared against	OFV	ΔOFV	SIG (P)b
One compartment
1	CL = θ1 · EXP(η)		1,158.2
	V = θ2 · EXP(η)
2	CL = θ1 · EXP(η + κ)	1	1,102.6	−55.6	<0.001
	V = θ2 · EXP(η + κ)
Two compartment
3	CL = θ1 · EXP(η)		484.40
	V1 = θ2 · EXP(η)
4	CL = θ1 · EXP(η + κ)	3	398.94	−85.5	<0.001
	V1 = θ2 · EXP(η + κ)
5	CL = θ1 · EXP(θ5 · (WT − 21)) · EXP(η + κ)	4	394.63	−4.31	<0.05
	V1 = θ2 · EXP(η + κ)
6	CL = θ1 · EXP(θ5 · (age − 6.5)) · EXP(η + κ)	4	396.20	−2.74
	V1 = θ2 · EXP(η + κ)
7	CL = θ1 · EXP(η + κ)	4	394.74	−4.20	<0.05
	V1 = θ2 · EXP(θ5 · (WT − 21)) · EXP(η + κ)
8	CL = θ1 · EXP(η + κ)	4	395.04	−3.90	<0.05
	V1 = θ2 · EXP(θ5 · (age − 6.5)) · EXP(η + κ)
9	CL = θ1 · EXP(θ5 · (WT − 21)) · EXP(η + κ)	5	380.93	−13.7	<0.001
	V1 = θ2 · EXP(θ6 · (WT − 21)) · EXP(η + κ)
10	CL = θ1 · EXP(θ5 · (WT − 21)) · EXP(η + κ)	9	382.10	1.16
	V1 = θ2 · EXP(θ6 · (WT − 21)) · EXP(θ7 · (age − 6.5)) · EXP(η + κ)

^aη, random variable of interindividual variability; κ, random variable of between occasion variability. WT is centered to the cohort median value of 21 kg; age is centered to the cohort median value of 6.5 years.

^bSIG, Significance of adding covariates into a model, assessed by P value.