TABLE 3.
L-AmB population parameter estimates from full model
| Parameter | Estimate (RSEa) | IIVb (RSE) | BOVc (RSE) |
|---|---|---|---|
| Structural | |||
| CL (l · h−1) | 0.44 (27) | 10 (40) | 46 (54) |
| V1 (l) | 3.12 (40) | 56 (64) | |
| Q (l · h−1) | 0.73 (18) | 77 (27) | |
| V2 (l) | 18.0 (40) | 74 (37) | |
| θ5d | 0.0152 (12) | ||
| θ6e | 0.0241 (29) | ||
| Residual variabilityf | |||
| Proportional (%) | 27 (7) | ||
| Additive (mg · l−1) | 0.034 (24) |
a
Relative standard error was calculated as a standard error/population estimate and is expressed as a percentage.
b
Interindividual variability is expressed as percent coefficient of variation (CV).
c
Between-occasion variability is expressed as percent CV.
d
θ5, effect of weight on CL.
e
θ6, effect of weight on V1.
f
The proportional error component of residual variability is expressed as percent CV; the additive error component of residual variability is expressed as standard deviation.