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Amino acid PRO (1 to 99) and CS (449, 452, and 453) sequences of clones derived from HIV-1HXB2 passaged under low-pressure selection of GW640385. Two clones (* and #) had a two-nucleotide insertion and a one-nucleotide deletion, respectively, resulting in a frame shift. X, undetermined amino acid. HIV-1HXB2 was passaged in the presence of GW640385 at the following concentrations: passage 1 (P1), 0.5 nM; P5, 1 nM; P10, 2 nM; P13, 3 nM; and P14, 5 nM.
