TABLE 1.
Cross-resistance of variants from the high- and low-selection analysisa
| PI | Resistance of variant
|
|||
|---|---|---|---|---|
| L10F/G16E/K20T/A28S/M46I/A71V/L449F/P453T
|
Q58E/A71V/R452K
|
|||
| IC50 (nM) | FR | IC50 (nM) | FR | |
| GW640385 | 45 ± 15 | >52.5 | 0.9 ± 0.2 | 2.4 |
| APV | 283 ± 110 | 8.7 | 20.9 ± 0.3 | 0.4 |
| LPV | 173 ± 98 | 15 | 24.6 ± 4.1 | 1.0 |
| SQV | 22 ± 9 | 2 | 15.7 ± 0.8 | 1.1 |
| NFV | 136 ± 17 | 5 | 26 ± 22.8 | 1.0 |
| IDV | 597 ± 293 | 55 | 56.8 ± 0.6 | 0.9 |
| ATZ | 16 ± 9 | 1 | 20.6 ± 1.1 | 1.4 |
a
FR, fold resistance, ratio of IC50 of test virus to that of HIV-1 strain HXB2; means and standard deviations for IC50s were calculated from two assays run in parallel for all drugs. APV, amprenavir; LPV, lopinavir; SQV, saquinavir; IDV, indinavir; NFV, nelfinavir; ATZ, atazanavir.