TABLE 3.

E_max model analysis for pharmacokinetic-pharmacodynamic relationship^a

Parameter	Emax		EPK50		R2
	Estimate	P	Estimate	P
Cmax
Day 1	3.33 ± 0.20	<0.0001	0.06 ± 0.03	0.087	0.9560
Steady state	3.44 ± 0.17	<0.0001	0.12 ± 0.04	0.006	0.9662
AUC0-t
Day 1	3.20 ± 0.17	<0.0001	0.13 ± 0.09	0.159	0.9538
Steady state	3.36 ± 0.16	<0.0001	0.41 ± 0.14	0.008	0.9663

^aModel estimates for E_max and EPK₅₀ are means ± SEs.