TABLE 3.

Univariate logistic regression models for microbiological success from the PK-PD efficacy analysis population (n = 55)

Parameter	Estimate	SE	Odds ratio	95% CIe for odds ratio		P
				Lower limit	Upper limit
AUC0-24 (μg · h/ml)	−0.0005	0.0016	1.00	0.996	1.00	0.77
AUC0-24/MIC	0.0001	0.0029	1.00	0.995	1.00	0.96
Cmax (μg/ml)	0.0015	0.0145	1.00	0.973	1.03	0.92
Cmax/MIC	0.0120	0.0235	1.01	0.967	1.06	0.61
% Time > MIC (%)	−0.0014	0.0368	0.999	0.929	1.07	0.97
Free-drug % time > MIC (%)	0.0007	0.0208	1.00	0.961	1.04	0.97
Free-drug % time > MIC ≥ 22%a	0.743	0.434	4.42	0.805	24.3	0.09
Preexisting diabetesb	−0.634	0.397	0.281	0.059	1.34	0.11
Ideal body wtc (kg)	0.743	0.434	4.42	0.805	24.3	0.09
Wtd (kg)	—	—	—	—	—	—
Age (yr)	−0.0068	0.0207	0.993	0.954	1.03	0.74

^aPatients with a free-drug % time > MIC less than 22% were used as the reference category.

^bPatients with no preexisting diabetes were used as the reference category.

^cIdeal body weight was assessed as a categorical covariate with patients less than 56.6 kg as the reference category.

^dWeight could not be assessed as a continuous covariate due to failure to meet assumptions of linearity, nor was it evaluated as a categorical covariate due to small sample size.

^eCI, confidence interval.