TABLE 4.

Univariate logistic regression models for microbiological success from the PK-PD efficacy analysis population excluding one medical outlier (n = 54)

Parameter	Estimate	SE	Odds ratio	95% CIe for odds ratio		P
				Lower limit	Upper limit
AUC0-24 (μg · h/ml)	0.0043	0.0029	1.00	0.999	1.01	0.14
AUC0-24/MIC	0.0102	0.0065	1.01	0.998	1.02	0.12
Cmax (μg/ml)	0.0279	0.0198	1.03	0.989	1.07	0.16
Cmax/MIC	0.0529	0.0347	1.05	0.985	1.13	0.13
% Time > MIC (%)	0.0026	0.0365	1.00	0.933	1.08	0.94
Free-drug % time > MIC (%)	0.0796	0.0512	1.08	0.980	1.20	0.12
Free-drug % time > MIC ≥ 22%a	1.09	0.560	8.84	0.984	79.5	0.05
Preexisting diabetesb	−0.523	0.413	0.352	0.070	1.77	0.21
Ideal body wtc (kg)	0.652	0.444	3.68	0.646	21.0	0.14
Wtd (kg)	—	—	—	—	—	—
Age (yr)	−0.0091	0.0220	0.991	0.949	1.04	0.68

^aPatients with a free-drug % time > MIC less than 22% were used as the reference category.

^bPatients with no preexisting diabetes were used as the reference category.

^cIdeal body weight was assessed as a categorical covariate with patients less than 56.6 kg as the reference category.

^dWeight could not be assessed as a continuous covariate due to failure to meet assumptions of linearity, nor was it evaluated as a categorical covariate due to small sample size.

^eCI, confidence interval.