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Mefloquine plasma concentrations in juvenile female rats at 72 h at various dose rates. Mefloquine plasma concentrations were highly correlated with dose (r2 = 0.938, P < 0.001, standard linear regression). Doses at which plasma concentrations were estimated to be 800 ng/ml (prophylaxis) and 2,100 ng/ml (treatment) were 45 and 187 mg/kg, respectively.
