Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Mefloquine induces neuronal damage in specific brain stem nuclei. Neuronal degeneration, as revealed by the presence of black-stained metallic granules, occurred in the nucleus gracilis (ng) after high-dose mefloquine treatment (765 mg/kg) (A). This effect was less pronounced with the 187-mg/kg dose (B) and was not observed with controls (C). The nucleus cuneatus (nc) and solitary (sol.) tract were affected to a lesser degree. Sections are stained with silver. Magnification, ×4.
