FIG. 6.

Effects of mefloquine on palpebral closure in the home cage during the light phase. Palpebral closure was monitored on a scale from 1 (eyes open) to 4 (eyes closed). Mefloquine induced a dose-dependent (P = 0.0023) and time-dependent (P < 0.0001) decrease in palpebral closure, although there was no significant interaction between dose and time (P = 0.11). There were no significant differences across groups for the predose palpebral closure data (P = 0.27). Significant differences were observed at 24 h for the 187- and 327-mg/kg treatment groups (P < 0.01 [indicated by an asterisk]).